• CCG-1423 RhoA Inhibitor: Workflow & Applications

  2026-08-22

  CCG-1423 is a pathway-focused RhoA inhibitor for separating MRTF-A nuclear signaling from actomyosin contractility. This article presents practical workflows for cancer research, apoptosis assays, invasion studies, and carefully controlled exploratory work on RhoA/ROCK-dependent barrier biology.

• Coumestrol for RA and ER Signaling Research

  2026-08-22

  Coumestrol is a phytoestrogen estrogen receptor antagonist that supports both rheumatoid arthritis fibroblast-like synoviocyte studies and broader nuclear receptor assays. Its value lies in pairing estrogen receptor pharmacology with a reference-supported PMAIP1, mitochondrial stress, and ferroptosis workflow.

• Catalpol in Cardio-Cerebrovascular Protection

  2026-08-21

  This comprehensive review maps how catalpol, an iridoid glucoside from Rehmannia glutinosa, may protect the heart and cerebrovascular system through antioxidant, anti-inflammatory, anti-apoptotic, and mitochondrial mechanisms. Its main practical contribution is an integrated framework connecting disease models, signaling pathways, pharmacokinetics, analytical control, and translational limitations.

• Cycloheximide in Apoptosis Mechanism Studies

  2026-08-20

  Cycloheximide is a powerful protein biosynthesis inhibitor for separating translation-dependent signaling from protein decay. This article explains how to use it to interpret Ku70 ubiquitination, mitochondrial remodeling, apoptosis, and protein turnover without confusing translational arrest with mechanism.

• Sulfo-NHS-LC-Biotin Protocol and QC Guide

  2026-08-20

  Sulfo-NHS-LC-Biotin provides water-compatible, irreversible biotin labeling of primary amines on proteins, peptides, and intact cell-surface proteins. It is suited to streptavidin-based detection, capture, and purification, but not to intracellular labeling or workflows that require reversible modification.

• NHS-Biotin for Protein Detection and Purification

  2026-08-19

  NHS-Biotin enables covalent, low-steric-hindrance labeling of antibodies, proteins, and intracellular targets for streptavidin-based detection or purification. This guide connects a practical amine-labeling workflow with peptidisc-assisted nanobody clustering, while separating established product use from emerging assay extensions.

• Itraconazole as a Biofilm Resistance Probe

  2026-08-19

  Itraconazole is more than a triazole antifungal agent: it can function as a controlled perturbation in Candida biofilm and resistance research. This article translates PP2A–autophagy findings into practical assay decisions while distinguishing antifungal, CYP3A4, hedgehog, and angiogenesis applications.

• Bradford Protein Assay Kit: Practical Workflow

  2026-08-18

  The Bradford Protein Assay Kit (SKU K4103) provides rapid protein concentration measurement for soluble samples used in enzyme assays, purification, and molecular biology. It is best used with compatible, low-interference matrices and should be avoided for high-detergent samples or peptides with insufficient basic or aromatic residues.

• A 83-01 (ALK Inhibitor) for Organoid Research

  2026-08-18

  A 83-01 enables controlled TGF-β pathway perturbation in EMT, fibrosis, growth-inhibition, and intestinal organoid assays. Its value is greatest when paired with hiPSC-derived intestinal models that separate 3D expansion from 2D pharmacokinetic testing.

• EZ Cap Cy5 Firefly Luciferase mRNA Workflow

  2026-08-17

  Track where an mRNA formulation goes with Cy5, then measure whether it produces functional protein with Firefly Luciferase. This dual-readout design helps separate delivery, intracellular persistence, and translation in transfection, carrier-screening, and imaging studies.

• 3-Bromopyruvate Reverses Cetuximab Resistance in CRC

  2026-08-17

  The reference study shows that combining 3-bromopyruvate with cetuximab can suppress colorectal cancer models that are intrinsically or adaptively cetuximab-resistant. Its central mechanistic contribution is the connection of FOXO3a restoration with AMPKα–Beclin1 signaling, PUMA activation, autophagy-dependent ferroptosis, and apoptosis.

• Z-IETD-FMK in Reliable Cell Death Assays

  2026-08-16

  Learn how Z-IETD-FMK (SKU B3232) can help researchers separate caspase-8-dependent apoptosis from general loss of viability, immune-cell activation effects, and downstream pyroptotic signaling. This scenario-based guide covers assay controls, stock preparation, interpretation, and practical product-selection criteria.

• Dexamethasone (DHAP) in Translational Inflammation

  2026-08-15

  Dexamethasone (DHAP) is more than a broad anti-inflammatory control: it can function as a mechanistic anchor across NF-κB signaling, stem cell differentiation, autophagy, osteosarcoma, and neuroinflammation workflows. This article connects recent rosemary-root natural-product findings with practical strategies for using a defined glucocorticoid anti-inflammatory in translational research.

• RP3-340N1.2, IL-6, and NSCLC Progression

  2026-08-14

  This study identifies the long non-coding RNA RP3-340N1.2 as a post-transcriptional regulator of IL-6 mRNA stability in non-small cell lung cancer. By combining RNA sequencing, gene-perturbation experiments, RNA decay analysis, RNA immunoprecipitation, and tumor–macrophage co-culture, the authors connect RP3-340N1.2 to malignant behavior and microenvironmental signaling.

• Coumestrol Drives PMAIP1-Linked Ferroptosis in RA

  2026-08-14

  A 2026 study identifies a mechanistic link between Coumestrol, mitochondrial PMAIP1 stabilization, and ferroptosis in rheumatoid arthritis fibroblast-like synoviocytes. The work suggests that redirecting the abnormal survival and inflammatory behavior of RA-FLS may complement conventional immune-focused strategies, while remaining an in vitro finding that requires further validation.

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