• Several studies have shown that independently of

  2019-11-02

  

  Several studies have shown that, independently of body-weight control, the central actions of leptin improve glycemic control in obese diabetic rat and mouse models [62]. For instance, restoration of OB-Rb expression in OB-Rb-deficient mice, and in particular in POMC neurons, was sufficient to norma

• br Activatable optical imaging probes Optical fluorescence

  2019-11-02

  

  Activatable optical imaging probes Optical fluorescence imaging, which directly detects photons emitted from fluorescent probes, has become as a powerful analytical method to study biological processes both in vitro and in vivo. It is characterized by high sensitivity, is free of radioactive irra

• Taken together our results demonstrate that the

  2019-11-01

  

  Taken together, our results demonstrate that the changes of striatal dopamine release and locomotor activity observed following chronic nicotine treatment and consequent acute withdrawal are mediated by CRF1, but not CRF2. Previous studies have already indicated that blocking CRF1 would prevent some

• br Results br Discussion In this

  2019-11-01

  

  Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 SB-505124 hydrochloride via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selecti

• Previous studies have indicated that hSSB

  2019-11-01

  

  Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho

• Intriguingly our laboratory has shown that the

  2019-11-01

  

  Intriguingly, our laboratory has shown that the I638F kinase domain mutant, unlike the L63V and G505 mutants, is incapable of receptor autophosphorylation and activation of its downstream effector SHP-2 when exposed to collagen stimulation. These data indicate that I638F is a loss of function mutati

• CVT 10216 In our ongoing investigation of the

  2019-11-01

  

  In our ongoing investigation of the structure activity relationship of benzenesulfonamide anti-inflammatory activity, we designed and synthesized a novel set of benzenesulfonamide derivatives starting from commercially available sodium saccharin. The pivotal features of our approach aimed to do some

• We did not find any significant associations between APOE

  2019-11-01

  

  We did not find any significant associations between APOE genotype and BDI-II, BAI, or PAI clinical scale scores. Our results indicate that APOE is not likely to play a major role in psychiatric comorbidities in epilepsy. This is in line with studies in the general population, which have not found a

• methylphenidate hcl australia br Acknowledgements br Introdu

  2019-11-01

  

  Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and methylphenidate hcl australia governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel prote

• Being a rare renal tumor its description

  2019-11-01

  

  Being a rare renal tumor, its description as primary renal tumor has been confined to the documentation of anecdotal case reports in the past [4], [9], [10], [11]. However, recent years have seen an increased interest in defining ES/PNET of kidney as a distinct entity, with the study undertaken by t

• Neutrophils produce high amounts of ROS which act as antimic

  2019-11-01

  

  Neutrophils produce high amounts of ROS, which act as antimicrobial agents, signaling molecules or initiators during PMA-induced NET formation. Of the intravenous anesthetics used in this study, propofol was the best at decreasing PMA-induced ROS levels (Fig. 3A and B). Our previous study also demon

• Methods br Results br Discussion In this study we make

  2019-11-01

  

  Methods Results Discussion In this study we make the novel observation that villin-1 and gelsolin are down-regulated in response to diverse cellular stressors, including bacteria associated with the pathogenesis of CD. The high plasticity and dynamics of the hydrochloride synthesis cytoskele

• br Introduction Cell transplantation therapies

  2019-10-31

  

  Introduction Cell transplantation therapies using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)-derived retinal tissue (ESC/iPSC retina) or selinexor have emerged as therapeutic options for retinal degeneration following recent breakthroughs. A number of groups have shown th

• Previously we have shown that the overexpression of ERR indu

  2019-10-31

  

  Previously, we have shown that the overexpression of ERRγ induces exercise-like oxidative muscle remodeling without engaging changes in the expression level or activity of PGC1α (Narkar et al., 2011). In this study, overexpression of ERRγ in PKO muscle reveals that ERRγ-activated target genes can ac

• Because of the lack of sequence current knowledge on the

  2019-10-31

  

  Because of the lack of sequence, current knowledge on the cellular regulation of CoA-IT is scarce. However, recent work has suggested an interesting new role for CoA-IT in regulating the extent of the AA mobilization response in primed macrophages. Bacterial lipopolysaccharide (LPS) is a poor trigge

16593 records 976/1107 page Previous Next First page 上5页 976977978979980 下5页 Last page