• Thus far a tight coupling has been observed between mAbs

  2025-02-28

  

  Thus far, a tight coupling has been observed between mAbs that target aggregated Aβ and the occurrence of ARIA. If ARIA-E is caused by increased trafficking to and clearance of fibrillar Aβ from cerebral vessels (20), mAbs could be designed with conformationally specific epitopes selective for solub

• The control group participants of the

  2025-02-28

  

  The control group participants of the current study were very similar in age to those of Puertas et al. There was no significant correlation between age and enzyme activity over the short age span studied although age-related changes in the activity of ApA and aspartyl aminopeptidase, typically incr

• br Results br Discussion By using an

  2025-02-28

  

  Results Discussion By using an unbiased proteomic screen for xCT binding partners, followed by functional validation, we have made the surprising discovery that mTORC2 regulates amino E-64-d metabolism in tumor cells by phosphorylating serine 26 of the cystine-glutamate antiporter xCT on its

• Interest in natural products has led to the

  2025-02-28

  

  Interest in natural products has led to the study of plant extracts as sources of ARIs. However, chemical complexity of natural extracts makes the identification of ARIs challenging and time-consuming. Identification of bioactive compounds with the desired biological effect from natural products, co

• Sodium Orthovanadate Toxicity is the main reason for

  2025-02-27

  

  Toxicity is the main reason for the failure at all stages of the new drug development process. The major part of safety-related attrition occurs at preclinical phases while predicting preclinical safety liabilities earlier in the drug development process. This strategy enables the design and/or sele

• br LOX in pancreatic cancer LOX is

  2025-02-27

  

  5-LOX in pancreatic cancer 5-LOX is a key player in pancreatic cancer (PC) progression. The upregulation of 5-LOX mRNA has been observed in pancreatic adenocarcinoma (PDAC) and also in neoplastic pancreatic tissues (Kennedy et al., 2003). Higher levels of 5-LOX transcripts (messengers) are presen

• Aurora kinases were initially identified as protein

  2025-02-27

  

  Aurora kinases were initially identified as protein kinases essential for error-free chromosome segregation during mitosis and meiosis. Aurora A appears to control premetaphase events, such as bipolar spindle assembly 3, 4, with Aurora B and C directing metaphase and postmetaphase events, including

• However most of these SBVS studies were focused on

  2025-02-27

  

  However, most of these SBVS studies were focused on the target(s) for which crystal structures were available or have a similar template in PDB for comparative modeling. Besides, these were limited to SBVS only which relies on the rigid binding pocket, therefore, it may result in high false positive

• It has been well established that shortly after

  2025-02-27

  

  It has been well established that shortly after systemic inflammation, NADPH oxidase and iNOS activity were increased in the ruthenium red and lead to overproduction of reactive oxygen species (ROS) and NO [66]. Moreover, previous studies indicated that Ang II induced an increased level of NADPH oxi

• Volatile esters are important to wine quality and

  2025-02-26

  

  Volatile esters are important to wine quality and to fresh berry grape flavor, especially in fox grapes (V. labrusca) [16]. Volatile esters such as Z-3-hexyl acetate can be found in V. vinifera ‘Cabernet Sauvignon’ berries albeit at low levels and their accumulation diminishes to below detection lev

• br Regulation of BCAA catabolism The BCAA catabolic system

  2025-02-26

  

  Regulation of BCAA catabolism The BCAA catabolic system is equipped in mammalian cells to dispose of excess BCAAs, presumably resulting in relatively stable concentrations of BCAAs in blood and tissues in humans. The main BCAA catabolic pathway is localized in the mitochondria of all tissues. The

• Ro 48-8071 br Materials and methods br Results br Discussion

  2025-02-26

  

  Materials and methods Results Discussion Wound healing of the human cornea is a complex process that requires cell migration and proliferation. Corneal wound healing is characterized by major changes in the composition of the ECM such as a massive transitory secretion of fibronectin combine

• Fenretinide A clear link between ADR stimulation

  2025-02-26

  

  A clear link between α2-ADR stimulation and decreased respiration in β-cells is established and consistent with proteomics data. Current discoveries in islets have identified physical interactions between ADR-coupled G proteins and cellular components such as insulin vesicles and ion channels (Zhao

• Introduction Glaucoma consists of a group of eye diseases

  2025-02-26

  

  Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion pantoprazole 40 mg uses and damage of the optical nerve. It is well accepted th

• Silk which is a mixture

  2025-02-26

  

  Silk, which is a mixture of mainly SF and sericin, has an extensive history in clinical application as a suture material. Unwanted immune reactions to silk sutures observed early on in their application were assigned to the presence of sericin. However, in vitro and in vivo evaluations of pure SF fi

16517 records 9/1102 page Previous Next First page 上5页 678910 下5页 Last page