• Multiple protein species are known to naturally exist for

  2021-05-19

  

  Multiple protein species are known to naturally exist for the transmembrane receptors DDR1 and DDR2. Five splice variants have been characterized for DDR1 (“a” through “e”). The d and e isoforms lack the intracellular kinase domain of DDR1. The splicing of DDR1 to various extents has been reported i

• Inappropriate heme metabolism has been linked to several

  2021-05-19

  

  Inappropriate heme metabolism has been linked to several neuropsychiatric disorders. In the hippocampi of Alzheimer's disease (AD) patients, for example, heme was found to binds intracellular amyloid β (Aβ), resulting in reduced heme bioavailability and its functional deficiency (Atamna and Frey, 20

• br Conclusion The present study is

  2021-05-19

  

  Conclusion The present study is the first to provide in vivo evidence that the σ1R deficiency can cause age-related increases in aggregation and phosphorylation of αSyn in dopaminergic neurons of SNpc. The σ1R has been reported to be decreased in the PEG Virus Precipitation Kit region of the nig

• dihydroxycholesterol OHC was recently identified by classic

  2021-05-19

  

  7α,25-dihydroxycholesterol (7α,25-OHC) was recently identified by classic analytical methods as a high-affinity ligand for EBI2 (Hannedouche et al., 2011; Liu et al., 2011). 7α,25-OHC was previously identified as an intermediate in the alternate pathway of hepatic bile crotaline synthesis (Russell,

• The first transcription factor TF known to interact with one

  2021-05-18

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone Ciclopirox of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed developmen

• br Materials and methods br Results and discussion br

  2021-05-18

  

  Materials and methods Results and discussion Conclusions Clitocypin is another member of the mycocypin family of cysteine protease inhibitors that is unique to Caffeine shown to exhibit strong insecticidal activity against Colorado potato beetle larvae. This effect is concentration depende

• POE specialises Rogers definition of engineering to systems

  2021-05-18

  

  POE specialises Rogers' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that fk506 meets a real-world need N to the satisfaction of a group of stakehol

• CDK lacks DNA binding domains

  2021-05-18

  

  CDK6 lacks DNA-binding domains and nuclear localization sequences, and therefore will probably be transported to the nucleus by a ‘piggy-back’ mechanism and needs to contact its specific sites indirectly through DNA-binding proteins. Besides NF-κB p65, a further candidate transcription factor is PAX

• 1186 br Results br Discussion This study assesses impacts of

  2021-05-18

  

  Results Discussion This study assesses impacts of HLA-DPB1 and CMV reactivation on GVHD, relapse, and OS after allo-HSCT. Here we demonstrate that HLA-DPB1 and CMV reactivation both increase aGVHD risk independently. Consistent with reported data, we show that HLA-DPB1 mismatching is associate

• br Disclosure statement br Acknowledgment This work

  2021-05-18

  

  Disclosure statement Acknowledgment This work was supported by the National Natural Science Foundation of China (81270704, 81330018). Background Over-expression of cyclooxygenase-2 (COX-2) is common in many malignancies including non-small cell lung cancer (NSCLC) and is associated with po

• ACAT may act as a dimer of

  2021-05-18

  

  ACAT1 may act as a dimer of dimer [38]. Within each dimer, it may contain two identical sterol substrate sites (designated as site S), and one or two sterol activator site(s) (designated as site A). Site S preferentially binds pregnenolone (PREG); it can also bind a variety of sterols that contain 3

• br Acknowledgements This study was financially

  2021-05-18

  

  Acknowledgements This study was financially supported by the National Special Research Programs for Non-Profit Trades (Agriculture) (Grant No. 201303045) and the Basic Foundation for Scientific Research of the State-level Public Welfare Institutes of China (Grant No. 2013JB10). Introduction L

• br Introduction Mammalian proteases comprise

  2021-05-18

  

  Introduction Mammalian proteases comprise both the peptidases or exopeptidases, which act at the N- or C-terminal positions of polypeptides, and proteinases or endopeptidases, which are capable of cleaving peptide bonds in the central regions of polypeptides. The endopeptidases are classified in

• A comparative analysis of the

  2021-05-18

  

  A comparative analysis of the cleavage activity of different forms of the BoNT/A endopeptidase in reduced conditions with SNAPtide and full-length SNAP-25 substrate is summarized in Fig. 5, Fig. 6. The BoNT/A LC was found to be the most active against SNAPtide, a small peptide segment of the SNAP-25

• OPP Several studies on the collagen receptor DDR have reveal

  2021-05-18

  

  Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR OPP on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DDR and integrin

16102 records 658/1074 page Previous Next First page 上5页 656657658659660 下5页 Last page