• Sulforaphane in Precision Inflammation Models: Beyond NLRP3

  2026-08-03

  Explore how sulforaphane advances oxidative stress response studies and cancer chemoprevention by uniquely targeting NLRP3 inflammasome pathways. This article reveals technical insights for assay design and translational research, offering a perspective distinct from standard workflows.

• Sulfo-NHS-LC-Biotin: Technical Guidance for Cell Surface Bio

  2026-08-03

  Sulfo-NHS-LC-Biotin enables irreversible, aqueous biotinylation of primary amines on proteins and peptides, particularly for labeling cell surface proteins without membrane penetration. This reagent is best suited for workflows requiring stable, extracellular modification; it should not be used for reversible or intracellular biotinylation tasks.

• Transmission Dynamics of Carbapenem-Resistant E. cloacae in

  2026-08-02

  This study systematically investigates carbapenemase-encoding genes (CEGs) in carbapenem-resistant Enterobacter cloacae from eight hospitals in Guangdong, China, during the COVID-19 pandemic. The findings reveal high rates of multidrug resistance, predominance of the blaNDM-1 gene, and extensive horizontal gene transfer, underscoring the need for robust surveillance in antimicrobial resistance research.

• Hypoxia and Immunometabolism in Tumor Microenvironment Dynam

  2026-08-01

  This review elucidates how hypoxia and immune metabolic reprogramming shape the tumor microenvironment, revealing the mechanisms that drive immunosuppression and tumor progression. Its synthesis of current evidence offers conceptual frameworks and methodological insights for researchers targeting glucose metabolism and immunometabolic pathways in cancer.

• OATP1B3 N-Glycosylation in Extracellular Loops 2 and 5: Func

  2026-07-31

  This study reveals that human OATP1B3 is significantly more N-glycosylated than its homolog OATP1B1, particularly in extracellular loops 2 and 5. The findings clarify how extensive N-glycosylation is critical for the surface expression and function of OATP1B3, with potential implications for liver disease and drug pharmacokinetics.

• PHF2 Histone Demethylase Regulates Neuroinflammation in Alzh

  2026-07-31

  This study identifies the histone demethylase PHF2 as a key regulator of inflammatory gene expression in Alzheimer’s disease (AD). By linking elevated PHF2 expression to neuroinflammatory processes, synaptic dysfunction, and memory loss, the research highlights new epigenetic intervention opportunities for AD and related neurodegenerative disorders.

• NHS-Biotin: Precision Biotinylation for Advanced Protein Eng

  2026-07-30

  Unlock the full potential of protein multimerization and cell-based assays with NHS-Biotin. This guide delivers actionable protocols, troubleshooting expertise, and insight into cutting-edge applications—from intracellular labeling to peptidisc-assisted clustering—making APExBIO’s NHS-Biotin indispensable for modern biochemical research.

• Cell Surface GlycoRNA–RBP Clusters Enable Peptide Uptake Pat

  2026-07-30

  This study reveals that RNA-binding proteins (RBPs) and glycoRNAs form organized nanoclusters on the cell surface, acting as essential domains for cell-penetrating peptide (CPP) entry, such as HIV TAT. The findings introduce a new layer of regulatory complexity in cell surface biology, advancing both the conceptual framework and experimental toolkit for studying membrane protein and RNA organization.

• Phosphoenolpyruvate Restricts cGAS-STING Inflammation in Agi

  2026-07-29

  A recent Nature Aging study reveals that phosphoenolpyruvate (PEP), a glycolytic metabolite, serves as an endogenous inhibitor of the cGAS–STING pathway, thereby reducing chronic inflammation associated with aging. These findings highlight metabolic intermediates as pivotal regulators of immune signaling and suggest new strategies for studying energy homeostasis and inflammation.

• Canagliflozin Hemihydrate: Precision Tools for Glucose Metab

  2026-07-29

  Explore how Canagliflozin hemihydrate empowers advanced glucose metabolism research with high specificity and robust protocol design. This article translates bench research into actionable workflows, highlights troubleshooting strategies, and contextualizes the compound's proven pathway selectivity.

• IPR-803: Urokinase Receptor Inhibitor for Tumor Invasion Stu

  2026-07-28

  IPR-803 stands out as a validated urokinase receptor inhibitor, enabling researchers to dissect tumor invasion and metastasis with precision. Its unique mechanism and proven efficacy in breast and pancreatic cancer models support both standalone and combination assay designs.

• AZD1480: Advanced JAK2 Inhibitor Workflows for STAT3 Pathway

  2026-07-28

  AZD1480 empowers cancer researchers to dissect and modulate the JAK2/STAT3 pathway with precision, driving innovation in both monotherapy and combination immunotherapy models. Its proven selectivity and robust in vitro and in vivo performance make it the gold standard for applied oncology workflows.

• Sulfo-NHS-SS-Biotin: Precision Cell Surface Protein Labeling

  2026-07-27

  The Sulfo-NHS-SS-Biotin Kit empowers researchers with reversible, high-specificity cell surface protein labeling—unlocking nanodomain mapping and dynamic interactome studies. Its water-soluble, disulfide-cleavable design enables robust affinity workflows with minimal background and seamless downstream analysis.

• AT-406 (SM-406): Optimized Apoptosis Induction in Cancer Res

  2026-07-27

  AT-406 (SM-406) stands out as a potent, orally bioavailable IAP antagonist, enabling reliable apoptosis pathway activation in diverse cancer models. This guide highlights workflow enhancements, troubleshooting strategies, and unique application insights, equipping researchers to maximize translational outcomes using AT-406 from APExBIO.

• Sulfo-NHS-LC-Biotin: Technical Guide for Cell Surface Biotin

  2026-07-26

  Sulfo-NHS-LC-Biotin is a water-soluble protein labeling reagent for covalent, irreversible biotinylation of primary amines, especially on cell surface proteins under fully aqueous conditions. It is unsuitable for intracellular or reversible biotinylation workflows due to its membrane-impermeable nature and the permanence of the amide bond it forms.

8722 records 6/582 page Previous Next First page 上5页 678910 下5页 Last page