• NHS-Biotin: Advancing Quantitative Protein Engineering an...

  2025-09-30

  Explore how NHS-Biotin, a premier amine-reactive biotinylation reagent, empowers quantitative and multiplexed strategies in protein engineering. This article uniquely bridges technical chemistry, functional multimerization, and next-generation intracellular applications.

• NHS-Biotin: Enabling Precision Intracellular Protein Labe...

  2025-09-29

  Explore how NHS-Biotin, a leading amine-reactive biotinylation reagent, empowers precision intracellular protein labeling for advanced nanobody and protein multimerization applications. This article offers a deep dive into its mechanistic and practical advantages, expanding beyond conventional approaches.

• NHS-Biotin in Multimeric Protein Engineering: Precision, ...

  2025-09-28

  Explore the unique advantages of NHS-Biotin, a leading amine-reactive biotinylation reagent, for engineering multimeric and multispecific proteins. This article reveals advanced strategies for stable intracellular protein labeling and functional assembly, setting it apart from conventional approaches.

• NHS-Biotin in Functional Proteomics: Enabling Dynamic Mul...

  2025-09-27

  Discover how NHS-Biotin, a leading amine-reactive biotinylation reagent, empowers dynamic protein multimerization and functional proteomics. This article uniquely explores the integration of NHS-Biotin in live-cell studies and advanced nanobody engineering, setting it apart from conventional guides.

• NHS-Biotin: Unveiling the Molecular Precision of Amine-Re...

  2025-09-26

  Explore how NHS-Biotin, a premier amine-reactive biotinylation reagent, enables unparalleled molecular precision in protein labeling and engineering. This article delves into the mechanistic, structural, and practical nuances of NHS-Biotin for intracellular and multimeric protein applications, offering a scientifically distinct perspective beyond standard protocols.

• Paclitaxel (Taxol) as a Precision Research Tool: Beyond C...

  2025-09-25

  Explore how Paclitaxel (Taxol), a potent microtubule polymer stabilizer, is revolutionizing cancer research and peripheral neuropathy modeling. This article uniquely highlights translational and mechanistic insights, addressing content gaps in current literature.

• HyperScribe™ T7 High Yield RNA Synthesis Kit: Pushing the...

  2025-09-24

  Explore how the HyperScribe T7 High Yield RNA Synthesis Kit transforms in vitro transcription RNA workflows for advanced functional genomics. This in-depth analysis uncovers its scientific mechanisms, unique advantages, and pivotal role in cutting-edge applications such as RNA vaccine research and CRISPR-based cancer studies.

• 5-Methyl-CTP: Optimizing mRNA Stability for Advanced Ther...

  2025-09-23

  Explore how 5-Methyl-CTP, a 5-methyl modified cytidine triphosphate, is revolutionizing mRNA synthesis with enhanced stability and translation efficiency—offering new opportunities for mRNA drug development and gene expression research.

• It has been largely demonstrated that several clinico

  2025-03-03

  

  It has been largely demonstrated that several clinico-pathological factors influence ovarian cancer patients' prognosis, including residual tumor at primary cytoreductive surgery, FIGO stage, tumor grading, cancer histology and performance status [3,4]. Nevertheless, the recent awareness achieved in

• The present study determined the effect of DCA

  2025-03-03

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that Y 134 non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascular calcificatio

• Pregnane X receptor PXR is a nuclear receptor that plays

  2025-03-03

  

  Pregnane X receptor (PXR) is a nuclear receptor that plays an important role in regulation of metabolism and disposition of structurally diverse xenobiotics as well as endogenous steroids and bile acids (Bertilsson et al., 1998, Kliewer et al., 1998, Lehmann et al., 1998). PXR regulates the metaboli

• Liver plays a pivotal role in metabolism

  2025-03-03

  

  Liver plays a pivotal role in metabolism of xenobiotic compounds, such as environmental contaminants and drugs. Some of these compounds generate hepatic damage and impair its function. It was well-known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could induce pathological changes in mouse and ra

• br Functions essentially consisting in transport of

  2025-03-03

  

  Functions essentially consisting in transport of substrates across plasma membranes Direct activation of neurotransmitter transporters elicits responses in neurons As previously mentioned (Section 2.1), nerve terminals handling classical transmitters possess transporters able to (re)capture se

• As the close paralog of adiponectin we

  2025-03-03

  

  As the close paralog of adiponectin, we hypothesized that CTRP9 could participate in regulation of reproduction. In order to evaluate whether Ctrp9 plays a role in the control of reproduction in tilapia, i.p. injection experiment was performed. HPG (Hypothalamic/pituitary/gonadal) axis plays a key r

• The enzyme plays an important

  2025-03-03

  

  The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host amyloid for its purine requirements and survival (Perrotto et al., 1971;

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