• GSTP is a class Glutathione S transferase GST

  2022-02-01

  

  GSTP1 is a π-class Glutathione S-transferase (GST-π) enzyme involved in tumor suppression by protecting thyrotropin releasing hormone against genomic damage mediated by various oxidants. Although the loss of GSTP1 function by hypermethylation has been reported as a common epigenetic alteration in p

• alzheimer's disease GnRH receptor GnRH R levels are elev

  2022-02-01

  

  GnRH receptor (GnRH-R) levels are elevated in decidualized stromal cells, suggesting a function for the GnRH–GnRH-R pathway in the early implantation events. Both GnRH and GnRH-R have been shown to be present in preimplantation embryos and the fallopian tubes at both mRNA and protein levels (). Two

• The amino hydroxy methyl isoxazolepropionic acid AMPA recept

  2022-02-01

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Wortmannin australia (AMPA) receptors are related ionotropic glutamate receptors (iGluRs) that mediate fast excitatory neurotransmission, and are also typically heteromeric ion channels, composed of GluA2 subunits in conjugation with GluA1, GluA3,

• Boswellia papyrifera Del Hochst mostly grows in Sudanian

  2022-02-01

  

  Boswellia papyrifera (Del.) Hochst., mostly grows in Sudanian and Sahelian regions and their oleo-gum resin is used medically in treatment of rheumatism, menorrhagia, amenorrhoea, vaginal infections, ulcers, sores, polyuria, syphilis, bronchitis, scrofulous affections, inflammations, asthma, diarrhe

• Analogous to all GPCRs the GLP R transduces

  2022-01-31

  

  Analogous to all GPCRs, the GLP-1R transduces signals from the outside of the cell to the inside by allosterically converting a ligand-binding event to activation of intracellular effectors. The GLP-1R couples to several intracellular effectors and this pleiotropic coupling is physiologically releva

• br Presenilins and apoptosis Apoptosis also known as

  2022-01-31

  

  Presenilins and apoptosis Apoptosis, also known as programmed cell death, has a critically important role in tissue homeostasis, development, normal ageing and the pathogenesis of several diseases, including cancer and neurological disorders. The presenilins were first linked to apoptosis when ce

• br Discussion br Author Contributions br Alzheimer s disease

  2022-01-31

  

  Discussion Author Contributions Alzheimer’s disease (AD) is an age-related, chronically progressive neurodegenerative disorder affecting more than 35million people worldwide and an estimated 5.5million in the US. Current marketed drugs such as acetylcholinesterase inhibitors and the NMDA ant

• n oxide The Hippo pathway has been well

  2022-01-31

  

  The Hippo pathway has been well established as a tumor suppressor pathway and is involved in many diverse biologic processes including cell growth, cell death, and organ size control in organisms, ranging from Drosophila to mammals [4]. Central to this pathway is a kinase cascade in which the Ste20-

• br Promotion of GLS expression Glutamine

  2022-01-31

  

  Promotion of GLS2 expression Glutamine metabolism is another target for alteration in ferroptosis. Glutamine is required for the induction of ferroptosis during serum-induced injury after amino Tolcapone starvation [72]. The first step of glutamine catabolism is its conversion to glutamate, whic

• A species specific diverse number of FPPS genes are

  2022-01-31

  

  A species-specific diverse number of FPPS genes are present in insect genomes (Zhang and Li, 2008, Cusson et al., 2006). The genome of the yellow fever mosquito Aedes aegypti contains a single FPPS gene (AaFPPS) that is highly expressed in the CA (Nouzova et al., 2011). FPPS catalytic activity in th

• Factor Xa FXa has emerged as a

  2022-01-31

  

  Factor Xa (FXa) has emerged as a particularly promising target for the development of effective anticoagulant drugs because FXa acts at the convergence point of the extrinsic and intrinsic coagulation pathways. It efficiently catalyzes the conversion of prothrombin to thrombin with one molecule of F

• In this study using the RBD Byr GST pull down

  2022-01-30

  

  In this study, using the RBD (Byr2)-GST pull-down assay associated with mass spectrometry, we also detected some kinases interacting with Ras-GTP under NO treatment. Among the kinases identified by mass spectrometry, we highlight Ste11 (designated Byr2 in S. pombe), Ste7 (Byr1) and Hog1. Interesting

• INTRODUCTION Scar formation and tissue regeneration

  2022-01-30

  

  INTRODUCTION Scar formation and tissue regeneration are opposite results of the wound healing process. Although fibrosis is more common after skin injury, full skin regeneration results in complete replacement of adnexa and function. Examples of tissue regeneration in mammalian systems include annu

• br Methods br Results and

  2022-01-30

  

  Methods Results and discussion Conclusions A third example of a hexokinase using polyphosphate exclusively as a phosphoryl donor has been identified, this time in mammalian tissues. This is the first polyphosphate utilizing enzyme activity demonstrated in mammalian Arecaidine but-2-ynyl est

• Methods br Results br Discussion

  2022-01-30

  

  Methods Results Discussion In this report, the therapeutic effect of a GCGR antagonistic antibody REMD2.59 was tested in 2 mechanistically divergent disease models of heart failure without confounding defects in global metabolism. Based on histological and functional analyses in both MI-injur

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