• In contrast to these findings Wang et al

  2018-10-25

  

  In contrast to these findings, Wang et al. [35], Rathke et al. [36], and Goracci et al. [37] showed the superiority of the “etch & rinse” adhesive system regarding the push-out strength of fiber-reinforced posts when compared to self-adhesive resin cements. Conflicting results could be attributed to

• With the development of laboratory medicine testing

  2018-10-25

  

  With the development of laboratory medicine, testing equipments are updated constantly, and the requirements for medical standards are gradually increased. With the increasing popularity of imported equipments in hospital, home-made facilities are increasingly replaced. In order to revitalize domest

• br Conclusion Our results demonstrate that

  2018-10-24

  

  Conclusion Our results demonstrate that the GAG mimetic [OTR4131] is able to enhance the critical human ECFC colony formation frequency, required to improve the amplification of ECFC, and to promote cell properties such as cell adhesion, migration and self-renewal. Moreover, [OTR4131] is able to

• In our current study IGFBP levels were

  2018-10-24

  

  In our current study IGFBP-2 levels were approximately 10-fold higher than those of IGFBP-3 suggesting that the large induction of IGFBP-2 may play a more import role in the differentiation of DPCs than the decrease seen in IGFBP-3 concentrations. Although an extensive literature describes both IGF-

• br Results To investigate the

  2018-10-24

  

  Results To investigate the dynamics of hCNS-SCns engraftment, we quantified SC121, a human cytoplasmic marker, in conjunction with bromodeoxyuridine (BrdU) or KI67, markers for mitotically active cells, or cleaved caspase 3 (CC3), a marker for cellular apoptosis. Lineage-specific differentiation

• you can find out more Using the combination of a mitogen

  2018-10-24

  

  Using the combination of a mitogen-activated protein kinase kinase (MEK) inhibitor, PD0325901 (PD03), and a glycogen synthase kinase 3 (GSK3) inhibitor, CHIR99021 (CHIR), which will hereafter be referred to as 2i, mouse ESCs (mESCs) are maintained in a ground state (Ying et al., 2008). CHIR activate

• We initially tested this system s

  2018-10-24

  

  We initially tested this system’s capacity to induce epigenetic reprogramming toward the SkM lineage in C3H10T1/2 thapsigargin previously shown to readily undergo this transformation (Davis et al., 1987). We designed three separate gRNAs (1–3) targeted to different positions proximal to the Myod1 t

• Here we describe the characteristics of a novel SeVdp iPS

  2018-10-24

  

  Here, we describe the characteristics of a novel SeVdp-iPS vector (SeVdp(KOSM)302L) containing miR-302a target sequences at the 3′-UTR of the L gene. This vector can be used for the efficient reprogramming of MEFs into transgene-free iPSCs without the aid of siRNAs, observed using human embryonic fi

• Our limited understanding of huSC biology can be attributed

  2018-10-24

  

  Our limited understanding of huSC biology can be attributed in part to the difficulty of obtaining tissue samples and of isolating a pure population of huSCs (Boldrin et al., 2010). By comparison, techniques for the prospective isolation of mouse SCs have identified a well-defined myogenic SC popula

• Gpr or T cell death associated gene Tdag is

  2018-10-24

  

  Gpr65, or T cell death-associated gene 8 (Tdag8), is a proton/acid-activated GPCR (Choi et al., 1996; Wang et al., 2004). Whereas GPR65 had not been linked to HSPC transitions, it was reported to be a pro-apoptotic factor in glucocorticoid-induced lymphocyte apoptosis (Malone et al., 2004) and to re

• SSC research was revolutionized by the development of

  2018-10-24

  

  SSC research was revolutionized by the development of spermatogonial transplantation in 1994 (Brinster and Zimmermann, 1994). This technique provided the first functional assay for SSCs and has been widely used to characterize SSCs. In initial attempts to improve the colonization efficiency of SSCs,

• br Results br Discussion In the meibomian gland low numbers

  2018-10-24

  

  Results Discussion In the meibomian gland, low numbers of LRCs were observed after 28, 42, and 56 days of chase, which fulfill the slow-cycling, undifferentiated, and low population criteria of adult epithelial stem Stem Cell Compound Library characterized in other tissues (Alonso and Fuchs,

• Our system is very similar to that developed by the

  2018-10-24

  

  Our system is very similar to that developed by the Poss Lab using the same ubiquitin promoter fragment (Chen et al., 2013), although their study did not use sedation routinely for BLI acquisition and allowed animals to swim freely (donor BLI was assessed 28 days post-HCT). By optimizing sedation an

• Microcephaly is a neurodevelopmental disorder where the head

  2018-10-24

  

  Microcephaly is a neurodevelopmental disorder where the head is smaller than the typical size during fetal development and at birth, with the circumference less than 2 SDs below the mean (Centers for Disease Control and Prevention, 2016b). Babies with microcephaly can have a wide array of problems s

• One major drawback of current melanoma therapy is the

  2018-10-24

  

  One major drawback of current melanoma therapy is the development of resistance mechanisms against novel therapeutics targeting the MAPK members RAF or MEK. Upon MAPK inhibition, additionally acquired mutations reactivate the MAPK pathway by gain of RAF gene copy numbers (Shi et al., 2012; Villanuev

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