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To confirm iPS identity and purity we
2018-11-12

To confirm iPS identity and purity, we checked embryonic stem cell makers, Tra-1-81 (Fig. 2A) and Tra-1-60 (not shown) by live staining and found all glucocorticoid receptor are Tra-1-81 positive. Acknowledgment The project described was supported by Award Number I21BX002215 (WX) from the Biome
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We and others have shown previously that
2018-11-09

We and others have shown previously that the evolutionarily conserved Notch signaling pathway plays an important role in early embryonic pituitary development (Kita et al., 2007; Raetzman et al., 2004, 2007; Zhu et al., 2006). Delta/Notch signaling, mediated by the critical transcription factor RBP-
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In addition to configurations for constitutive gene expressi
2018-11-09

In addition to configurations for constitutive gene expression, we also tested the behavior of the Tet-on system (http://www.clontech.com) in which sequences encoding either GFP or mCherry expression were placed under the control of a doxycycline-responsive promoter. Although robust doxycycline-indu
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Finally we suggest a potential
2018-11-09

Finally, we suggest a potential mode of action for the observed neuroprotective effects following grafting of IL-13-producing MSCs. Based on our data, and in agreement with current literature, we can put forward two mechanistic explanations. Firstly, it has been shown that a reduction in CX3CR1 sign
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br Summary br Acknowledgment br The study
2018-11-09

Summary Acknowledgment The study is supported by the Ministry of Education and Science of the Russian Federation (government grant). Introduction Ferroelectric composites can be of various structures which are formed by polar particles in different matrixes: in weakly or strongly pola
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It follows from the obtained distributions that the trends d
2018-11-09

It follows from the obtained distributions that the trends discovered in the early loading stages became persistent and unambiguous: the magnitude of acoustic anisotropy in the regions of maximum plastic strain exceeded that of the anisotropy in the midpoints of the working area by nearly two times
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The bioenergetic system of the brain
2018-11-09

The bioenergetic system of the Cy5.5 hydrazide is compromised early in the progression of AD and is evident during the prodromal (preclinical) stage of the disease (Mosconi, 2005; Mosconi et al., 2006, 2009b; Reiman et al., 1996, 2004; Yao et al., 2009, 2011b; Brinton et al., 2015; Moreira et al.,
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The goal of organ on
2018-11-09

The goal of organ-on-a-chip devices is to recapitulate tissue- and organ-level functions in a simple, yet easily manipulated apparatus. The simplest systems involve the growth of one or more cell types in a single, perfused microfluidic chamber to exhibit the functions of one tissue type. More compl
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The Adipose Graft Transposition Procedure AGTP uses patient
2018-11-09

The Adipose Graft Transposition Procedure (AGTP) uses patient\'s existing cardiac fat directly, placing it over the myocardial infarcted zones, rather than explanting a cardiac adipose biopsy to retrieve the Sodium phosphate monobasic (Gálvez-Montón et al., 2011; Gálvez-Montón et al., 2013b). In th
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M tuberculosis has been considered innately resistant to lac
2018-11-09

M. tuberculosis has been considered innately resistant to β-lactam antibiotics, due to β–lactamase activity and the presence of non-classical transpeptidases in their cell wall (Hugonnet et al., 2009; Gupta et al., 2010). M. tuberculosis possesses a highly active β-lactamase, BlaC, that rapidly hydr
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br The Case for Systemic Administration of
2018-11-09

The Case for Systemic Administration of Oncolytic Viruses While Imlygic and several other OV platforms are designed as loco-regional therapeutics, for a variety of reasons, intravenous administration ultimately may be the preferred route of delivery (Naik et al., 2012). Metastatic or widespread c
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The authors identified other genetic variants that are promi
2018-11-09

The authors identified 13 other genetic variants that are promising candidates. None of these additional genetic variants reached the pre-specified level of statistical significance and therefore do not meet the discovery threshold but remain as promising candidates requiring further work and valida
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br Introduction Recurrent hypersomnia RH is a rare
2018-11-09

Introduction Recurrent hypersomnia (RH) is a rare disorder that generally affects teenagers and is characterized by episodes of excessive sleep lasting up to several days, when patients sleep almost all day and rise only to eat and void. When associated with behavioral or cognitive disturbances,
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Pero el proyecto m s interesante fue el establecimiento
2018-11-09

Pero el proyecto más interesante fue el establecimiento en 1998 de una Joint venture llamada Gunderson-Concarril con el más importante fabricante de barcazas marinas, equipos ferroviarios y terrestres de carga en Estados Unidos, The Greenbrier Companies, para la fabricación y reparación de furgones,
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br Introduction Although the incidence of
2018-11-09

Introduction Although the incidence of HIV has peaked in much of sub-Saharan Africa, the tuberculosis (TB) epidemic continues unabated with TB remaining the leading cause of death in those living with HIV (World Health Organization, 2014). While many studies have investigated the impact of HIV in
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