• Categorization of AD in the epidemiological simulations diff

  2018-11-05

  

  Categorization of AD in the epidemiological simulations differs from some previous studies for China and the US (Wang et al., 2008; AA, 2015) which employed a three-state (mild, moderate, severe) categorization. The current two-state specification of AD (stage 1 and stage 2) encapsulates mild and mo

• tryptophan hydroxylase The high burden of ocular

  2018-11-05

  

  The high burden of ocular disease in CKD can be explained, in part, by the sharing of risk factors common to both kidney and eye diseases such as age, smoking, hypertension, diabetes, raised serum cholesterol and obesity. Ocular diseases may also be directly linked to CKD via common pathogenic pathw

• pten pathway br Author Contributions br Conflicts of

  2018-11-05

  

  Author Contributions Conflicts of Interest Introduction Severe influenza occurs each winter especially in high-risk groups such as young children, older adults, patients with pulmonary conditions, inflammatory conditions, malignancies, and pregnant women (Newton et al., 2000; Schanzer et al

• br Methods br Results VIS

  2018-11-05

  

  Methods Results VIS410 is an engineered human IgG1 antibody that targets a unique, conserved conformational epitope on the stem of Influenza A virus HA protein (Tharakaraman et al., 2015). Previous studies have identified that VIS410 has broad reactivity against both group 1 and group 2 influe

• br Materials and Methods br Results br Discussion The

  2018-11-05

  

  Materials and Methods Results Discussion The prophylactic tolerance protocol entails the administration of immunosuppressive drugs. Rapamycin is an mTOR inhibitor approved for immunosuppression in organ transplantation (and is commonly used in children (Ganschow et al., 2013)) and has pote

• parp apoptosis pathway The main finding of the study was tha

  2018-11-05

  

  The main finding of the study was that CPAP therapy for one month led to significant improvements in parp apoptosis pathway morphology, daytime sleepiness and verbal episodic memory function in the BSC+CPAP group compared with the BSC only group. These early hypertrophic morphological changes appea

• br Methods br Results br

  2018-11-05

  

  Methods Results Discussion Peritoneal micro-metastases are a common occurrence and portend poor prognosis for many malignancies including ovarian, gastric, and pancreatic cancer (Ferrone et al., 2006; Merchant et al., 1999; Bentrem et al., 2005; Burke et al., 1998; Yachida et al., 2002; Yos

• One of the key findings of

  2018-11-05

  

  One of the key findings of this study is that the FcMBL ELLecSA detected PAMPs released from 47 of 55 (92%) clinically relevant pathogen species screened, including 14 of 16 of the most frequent bacterial species associated with sepsis at two major academic clinical medical centers (Brigham and Wome

• mdm2 inhibitor br Future Directions The mechanisms linking I

  2018-11-05

  

  Future Directions The mechanisms linking IL-33-mediated T-cell proliferation and/or survival to cytokine production will benefit from further in vivo studies. The interaction of IL-33 with other IL-1 family members, such as IL-18, needs to be thoroughly investigated to identify potential synergis

• The significant SNPs lie in

  2018-11-05

  

  The significant SNPs lie in non-coding regions, as is common in GWAS where ~64% of identified SNPs lie in enhancer regions (Hnisz et al., 2013). Gene enhancer elements are noncoding segments of DNA involved in regulating transcriptional programs (Corradin and Scacheri, 2014). Their location is predi

• The significant SNPs lie in

  2018-11-05

  

  The significant SNPs lie in non-coding regions, as is common in GWAS where ~64% of identified SNPs lie in enhancer regions (Hnisz et al., 2013). Gene enhancer elements are noncoding segments of DNA involved in regulating transcriptional programs (Corradin and Scacheri, 2014). Their location is predi

• This study found that the

  2018-11-05

  

  This study found that the median CPT over time showed a greater decrease in the control group than the ep4 receptor group. While both groups were given ranibizumab injections at baseline and week 4, the gene therapy group patients received a core vitrectomy, associated with subretinal gene therapy,

• cytoskeleton In the actual experiments the gas flow

  2018-11-05

  

  In the actual experiments, the gas flow rates were operated in the range of 8.297 × 10−4 m3/s to 27.65 × 10−4 m3/s and the liquid flow rates were in the range 20.649 × 10−6 m3/s to 48.183 × 10−6 m3/s. As the experiment proceeds, the liquid started forming a layer which is clear liquid (ScL) and its

• A detailed analysis of hypocretinergic neuronal activity

  2018-11-05

  

  A detailed analysis of hypocretinergic neuronal activity shows that these neurons are strongly activated when animals are exploring an unknown environment (exploratory motor activity) [50]. In fact, in this study, the number of Hcrt+Fos+neurons was approximately 10 times greater during exploratory m

• br Medical literature robustly supports a close link between

  2018-11-05

  

  Medical literature robustly supports a close link between sleep disorders and psychiatric disorders. Recently, the co-occurrence of sleep dysfunctions and psychotic experiences (particularly insomnia with paranoia) has been reported, although the causal relationship is still unclear . Moreover, Re

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