• hESC NPCs and hfNPCs induced different PBMC proliferative re

  2018-11-12

  

  hESC-NPCs and hfNPCs induced different PBMC proliferative responses, despite relatively similar expression levels of HLA, co-stimulatory and adhesion molecules. Multiple other factors that are produced by NPCs and may contribute to the regulation of the immune response such as inducible nitric oxide

• Paradoxically we found that mutant K Ras

  2018-11-12

  

  Paradoxically, we found that mutant K-Ras increases proliferation of quiescent intestinal stem purchase Manumycin A (Fig. 2), but also increases repair following damage (Fig. 3). This phenomenon is similar to the role that oncogenic N-Ras plays in hematopoietic stem cells (HSCs) (Li et al., 2013).

• br Materials and methods br

  2018-11-12

  

  Materials and methods Results and discussion Acknowledgments Introduction Reprogramming rejuvenates aged somatic cells back into the pluripotent state (Takahashi et al., 2007; Takahashi and Yamanaka, 2006). The developmental plasticity of induced pluripotent stem cells (iPSC) demonstrate

• To confirm iPS identity and purity we

  2018-11-12

  

  To confirm iPS identity and purity, we checked embryonic stem cell makers, Tra-1-81 (Fig. 2A) and Tra-1-60 (not shown) by live staining and found all glucocorticoid receptor are Tra-1-81 positive. Acknowledgment The project described was supported by Award Number I21BX002215 (WX) from the Biome

• We and others have shown previously that

  2018-11-09

  

  We and others have shown previously that the evolutionarily conserved Notch signaling pathway plays an important role in early embryonic pituitary development (Kita et al., 2007; Raetzman et al., 2004, 2007; Zhu et al., 2006). Delta/Notch signaling, mediated by the critical transcription factor RBP-

• In addition to configurations for constitutive gene expressi

  2018-11-09

  

  In addition to configurations for constitutive gene expression, we also tested the behavior of the Tet-on system (http://www.clontech.com) in which sequences encoding either GFP or mCherry expression were placed under the control of a doxycycline-responsive promoter. Although robust doxycycline-indu

• Finally we suggest a potential

  2018-11-09

  

  Finally, we suggest a potential mode of action for the observed neuroprotective effects following grafting of IL-13-producing MSCs. Based on our data, and in agreement with current literature, we can put forward two mechanistic explanations. Firstly, it has been shown that a reduction in CX3CR1 sign

• br Summary br Acknowledgment br The study

  2018-11-09

  

  Summary Acknowledgment The study is supported by the Ministry of Education and Science of the Russian Federation (government grant). Introduction Ferroelectric composites can be of various structures which are formed by polar particles in different matrixes: in weakly or strongly pola

• It follows from the obtained distributions that the trends d

  2018-11-09

  

  It follows from the obtained distributions that the trends discovered in the early loading stages became persistent and unambiguous: the magnitude of acoustic anisotropy in the regions of maximum plastic strain exceeded that of the anisotropy in the midpoints of the working area by nearly two times

• The bioenergetic system of the brain

  2018-11-09

  

  The bioenergetic system of the Cy5.5 hydrazide is compromised early in the progression of AD and is evident during the prodromal (preclinical) stage of the disease (Mosconi, 2005; Mosconi et al., 2006, 2009b; Reiman et al., 1996, 2004; Yao et al., 2009, 2011b; Brinton et al., 2015; Moreira et al.,

• The goal of organ on

  2018-11-09

  

  The goal of organ-on-a-chip devices is to recapitulate tissue- and organ-level functions in a simple, yet easily manipulated apparatus. The simplest systems involve the growth of one or more cell types in a single, perfused microfluidic chamber to exhibit the functions of one tissue type. More compl

• The Adipose Graft Transposition Procedure AGTP uses patient

  2018-11-09

  

  The Adipose Graft Transposition Procedure (AGTP) uses patient\'s existing cardiac fat directly, placing it over the myocardial infarcted zones, rather than explanting a cardiac adipose biopsy to retrieve the Sodium phosphate monobasic (Gálvez-Montón et al., 2011; Gálvez-Montón et al., 2013b). In th

• M tuberculosis has been considered innately resistant to lac

  2018-11-09

  

  M. tuberculosis has been considered innately resistant to β-lactam antibiotics, due to β–lactamase activity and the presence of non-classical transpeptidases in their cell wall (Hugonnet et al., 2009; Gupta et al., 2010). M. tuberculosis possesses a highly active β-lactamase, BlaC, that rapidly hydr

• br The Case for Systemic Administration of

  2018-11-09

  

  The Case for Systemic Administration of Oncolytic Viruses While Imlygic and several other OV platforms are designed as loco-regional therapeutics, for a variety of reasons, intravenous administration ultimately may be the preferred route of delivery (Naik et al., 2012). Metastatic or widespread c

• The authors identified other genetic variants that are promi

  2018-11-09

  

  The authors identified 13 other genetic variants that are promising candidates. None of these additional genetic variants reached the pre-specified level of statistical significance and therefore do not meet the discovery threshold but remain as promising candidates requiring further work and valida

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