• M tuberculosis has been considered innately resistant to lac

  2018-11-09

  

  M. tuberculosis has been considered innately resistant to β-lactam antibiotics, due to β–lactamase activity and the presence of non-classical transpeptidases in their cell wall (Hugonnet et al., 2009; Gupta et al., 2010). M. tuberculosis possesses a highly active β-lactamase, BlaC, that rapidly hydr

• br The Case for Systemic Administration of

  2018-11-09

  

  The Case for Systemic Administration of Oncolytic Viruses While Imlygic and several other OV platforms are designed as loco-regional therapeutics, for a variety of reasons, intravenous administration ultimately may be the preferred route of delivery (Naik et al., 2012). Metastatic or widespread c

• The authors identified other genetic variants that are promi

  2018-11-09

  

  The authors identified 13 other genetic variants that are promising candidates. None of these additional genetic variants reached the pre-specified level of statistical significance and therefore do not meet the discovery threshold but remain as promising candidates requiring further work and valida

• br Introduction Recurrent hypersomnia RH is a rare

  2018-11-09

  

  Introduction Recurrent hypersomnia (RH) is a rare disorder that generally affects teenagers and is characterized by episodes of excessive sleep lasting up to several days, when patients sleep almost all day and rise only to eat and void. When associated with behavioral or cognitive disturbances,

• Pero el proyecto m s interesante fue el establecimiento

  2018-11-09

  

  Pero el proyecto más interesante fue el establecimiento en 1998 de una Joint venture llamada Gunderson-Concarril con el más importante fabricante de barcazas marinas, equipos ferroviarios y terrestres de carga en Estados Unidos, The Greenbrier Companies, para la fabricación y reparación de furgones,

• br Introduction Although the incidence of

  2018-11-09

  

  Introduction Although the incidence of HIV has peaked in much of sub-Saharan Africa, the tuberculosis (TB) epidemic continues unabated with TB remaining the leading cause of death in those living with HIV (World Health Organization, 2014). While many studies have investigated the impact of HIV in

• We characterized structural disease load using volumetric me

  2018-11-09

  

  We characterized structural disease load using volumetric measures of the caudate, putamen, global gray and global white matter that show sensitivity towards HD-related changes (Tabrizi et al., 2012). These structural markers of disease load were included in a systematic examination of both order AM

• Based on the original discoveries the S

  2018-11-09

  

  Based on the original discoveries, the S2R has been authentically defined as a high-affinity DTG binding site with a molecular weight at 18–21kDa (Bowen et al., 1989; Hellewell and Bowen, 1990; Hellewell et al., 1994; Itzhak, 1987; Weber et al., 1986). According to this definition, the results prese

• Hepatitis B virus HBV infections are

  2018-11-09

  

  Hepatitis B virus (HBV) infections are frequent in sub-Saharan Africa and Asia with infection rates between 8% and 20% (WHO, 2013). In Vietnam, approximately 10 million (10%) individuals live with chronic inno-206 (Dunford et al., 2012; Nguyen, 2012). HEV superinfection in patients with chronic HBV

• br Results and discussion br Material and methods br

  2018-11-08

  

  Results and discussion Material and methods Conclusions There are various applications for cell-based therapies in cartilage repair. For knee cartilage lesion treatment, autologous chondrocyte transplantation has become the principal cell-based approach. The first human autologous chondrocy

• br Results and Discussion br

  2018-11-08

  

  Results and Discussion Experimental Procedures Acknowledgments Introduction Primordial germ BAY 87-2243 (PGCs) are the founders of germ cells that give rise to eggs and sperm as the end products (Surani, 2007). In mice, extraembryonic tissues direct a small number of pluripotent epiblas

• While the facial skeleton is formed by HOX negative neural

  2018-11-08

  

  While the facial skeleton is formed by HOX negative neural crest lpa receptor (Creuzet et al., 2002), the skeleton, originating from mesoderm-derived progenitor cells, is usually HOX positive in adults (Leucht et al., 2008). In bone regeneration experiments, Leucht et al. revealed that the HOX negat

• When BMSCs act as target cells

  2018-11-08

  

  When BMSCs act as target cells, the canonical β-catenin signaling pathway can be stimulated in response to Wnt1, Wnt3a, and Wnt8 or by inhibition of GSK-3 (Westendorf et al., 2004). Wnt/β-catenin directly stimulates Runx2 gene 69 9 via the TCF-binding site (Gaur et al., 2005). In the present study,

• Although colorectal CSCs Co CSCs were

  2018-11-08

  

  Although, colorectal CSCs (Co-CSCs) were originally identified as a small group of CD133+ dpn present in the primary tumors which exhibited high tumorigenicity in immunodeficient mice (O\'Brien et al., 2007; Ricci-Vitiani et al., 2007), some studies have shown that CD44+ colorectal cancer cells als

• br Acknowledgments We thank Mrs Jessica Franzot

  2018-11-08

  

  Acknowledgments We thank Mrs Jessica Franzot for technical support with Western blotting. This work was supported by grants from the government of the Friuli Venezia Giulia Region (SPINAL project), the Fund for Transregional Cooperation (MINA project), and the IBRO Return Home Programme Grant (to

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