• One major drawback of current melanoma therapy is the

  2018-10-24

  

  One major drawback of current melanoma therapy is the development of resistance mechanisms against novel therapeutics targeting the MAPK members RAF or MEK. Upon MAPK inhibition, additionally acquired mutations reactivate the MAPK pathway by gain of RAF gene copy numbers (Shi et al., 2012; Villanuev

• br Particle motion near the plane of symmetry is

  2018-10-24

  

  Particle motion near the plane of symmetry is usually studied in so-called paraxial approximation, taking into account terms in till only. It is interesting to carry out a numerical experiment for estimating a real number of terms needed. Analytical calculations may be rather cumbersome, but they

• In this contribution we treat the growth

  2018-10-24

  

  In this contribution, we treat the growth of fullerenes as a series of joining reactions of cupola half-fullerenes C10, C12, C16, C20, and C24[9] through the use of the geometrical modeling. Reaction between two base-truncated triangular pyramids The atomic configurations corresponding to reacti

• The present study has considered the generation of the

  2018-10-24

  

  The present study has considered the generation of the third harmonic. The ratio of the voltage amplitude at the frequency 3ω to the amplitude of the voltage applied to the sample, i.e., the third harmonic coefficient γ3ω[14], was used as the quantity characterizing the generation intensity. The fie

• The asymptotic form for the

  2018-10-24

  

  The asymptotic form for the SIF provided that ɛ → 0 follows from (22): Thus, the behavior of the SIF at small distances from the crack tip to the inclusion vertex is governed by the value of the first root of Eq. (23). The following three variants are possible if ɛ → 0: Similar behavior of the

• br Conflict of interest statement br Acknowledgements The au

  2018-10-24

  

  Conflict of interest statement Acknowledgements The authors wish to acknowledge the support of colleagues in the AGEGlobe Network funded under the ESRC Ageing and Well-being in a Globalising World (grant number ES/K005979/1) and the ESRC Centre for Population Change (grant number ES/K007394/1)

• This evidence is in line with previous empirical

  2018-10-24

  

  This evidence is in line with previous empirical investigations conducted on the UK with BHPS data by Giordano and Lindström (2011) and Lindström and Giordano (2016) which use active participation in associations as structural social capital and an index of self-rated psychological health obtained f

• We first estimate the pseudo panel

  2018-10-23

  

  We first estimate the pseudo-panel model by weighted least squares at the cell level, with the dependent variable being the logarithm of the real hourly wage (lw), and the explanatory variables are: proficiency in the 11th grade (lprof), various observed cell characteristics, such as parental educat

• The essential autophagy gene beclin BECN is

  2018-10-23

  

  The essential autophagy gene beclin 1 (BECN1) is a haploinsufficient tumor suppressor (Liang et al., 1999; Qu et al., 2003; Yue et al., 2003) that is also located on the breast cancer tumor susceptibility chromosomal locus 17q21, ~150kb centromeric to BRCA1 (Aita et al., 1999). Monoallelic loss of B

• Interestingly when we stratified our cohort by infant sex mo

  2018-10-23

  

  Interestingly, when we stratified our cohort by infant sex, more BI6727 showed an association with arsenic exposure, and many of these associations were sexually dimorphic. In keeping with these results, previous studies have suggested that in utero arsenic exposure has differential effects on male

• br Introduction Advances in the treatment of HIV infection h

  2018-10-23

  

  Introduction Advances in the treatment of HIV infection have dramatically reduced AIDS mortality and improved the quality of life of many people living with HIV (Palella et al., 1998). The initiation of ART results in a rapid drop in plasma viral load and in a substantial reduction in the number

• br Discussion Nowadays the expected long term survival

  2018-10-23

  

  Discussion Nowadays, the expected long-term survival of the vast majority of patients with CAD is excellent, with few recurrent cardiovascular events (Bauters et al., 2014a). During this prolonged period of outpatient care, diagnostic and therapeutic decisions by the referring cardiologist are ma

• Over the two centuries we have observed that the

  2018-10-23

  

  Over the two centuries, we have observed that the DEP in Athens, Malága, and Rome are consistently over the threshold during part of the year. Nice stands out as having the most dramatic rise; by the 2060, Nice would surpass the intensity of the three Southern European cities; by the end of this An

• br Materials and Methods br

  2018-10-23

  

  Materials and Methods Results Discussion The prophylactic tolerance protocol entails the administration of immunosuppressive drugs. Rapamycin is an mTOR inhibitor approved for immunosuppression in organ transplantation (and is commonly used in children (Ganschow et al., 2013)) and has poten

• Gut Microbiome and Inflammatory Bowel

  2018-10-23

  

  Gut Microbiome and Inflammatory Bowel Disease Modulation of Gut Microbiota in Obesity and Cardiometabolic Disorders Changes in gut microbiota are associated with metabolic disorders such as obesity, type 2 diabetes and cardiovascular risk factors. Patrice D. Cani (Brussels, Belgium), Willem M. d

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