• br Declarations Funding None for

  2024-08-08

  

  Declarations Funding: None for the paper in question. Competing interests: Florent Morio has received speaker's fees from Gilead, Basilea, and MSD and travel grants from Gilead, MSD, Pfizer, Basilea, and Astellas. Ethical approval: Not relevant for the paper in question. Introduction Lactic

• As patients with type diabetes are known to

  2024-08-08

  

  As patients with type 2 diabetes are known to be hyperinsulinemic per se, this relationship between insulin/IGF1 receptor and AR may point towards a causal role of insulin in AR upregulation. Indeed, this is supported by several previous observations. Beyond the already mentioned AR activation by in

• In our study we provide evidence for the existence of

  2024-08-08

  

  In our study we provide evidence for the existence of an endosome-lysosomal pathway for the proteolytic degradation of AR triggered by its interaction with the ESCRT-I component TSG101. The following findings of this study support this notion: (1) We showed that TS101 interacts with endogenous or ec

• br Conclusions br Transparency document

  2024-08-08

  

  Conclusions Transparency document Acknowledgements This work was supported by a grant from the European Commission FP6 “Neuroprion” – Network of Excellence and Royal Veterinary College Bioveterinary science research project funding. We thank Professor Alun Williams (Cambridge University) fo

• Inhibition of autophagy has been shown

  2024-08-07

  

  Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention

• br STAR Methods br Author Contributions

  2024-08-07

  

  STAR★Methods Author Contributions Acknowledgments This study is funded by National Institutes of Health (NIH) Grants NS028901 and DC004450 (to L.O.T.); N.L. Tartar Trust Fellowship (to H.-W.L.); DC014878 to T.S.B. We thank members of the Trussell lab for helpful discussions, Dr. Stephen Dav

• With regard to participation of the S lipoxygenase

  2024-08-07

  

  With regard to participation of the 12S-lipoxygenase in diabetes mellitus, inconsistent results have been obtained. Earlier studies demonstrated that the leukocyte-type 12S-lipoxygenase is specifically expressed in pancreatic b-cells and is involved in regulating glucose-stimulated insulin secretion

• In the QFP rs T allele showed a significant

  2024-08-07

  

  In the QFP, rs2269657-T allele showed a significant correlation with reduced plaque density in frontal cortices (Table 2), strengthening the association with amyloid pathology. The same histone methyltransferase inhibitor region was shown to exhibit a statistically significant reduction of SREBF2 mR

• In our previous study we found that the total

  2024-08-07

  

  In our previous study we found that the total activity of aldehyde dehydrogenase in cancer Ki16425 synthesis of RCC is at the same level as in normal renal tissue [10]. These findings are similar to our results in serum patients with renal cancer. There is no significant difference between ALDH acti

• To determine the post translation modifications in chicken a

  2024-08-07

  

  To determine the post-translation modifications in chicken adiponectin, we isolated adiponectin from chicken adipose tissue by immunoprecipitation. Chicken adiponectin was then subjected to tryptic digestion and UPLC/MS/MS. The collagenous domain of chicken adiponectin was found to possess certain n

• Although the effects of adenosine receptor signaling in acut

  2024-08-07

  

  Although the effects of adenosine receptor signaling in acute renal IRI have been attributed to the generation of high concentrations of adenosine, we have recently reported an increase in kidney levels of both AMP and adenosine, with a concomitant fall in ATP and ADP. We have also previously demons

• Gap19 br Actin cytoskeleton in protrusion Pushing force driv

  2024-08-07

  

  Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing Gap19 filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lamellipo

• elastase Genetic observations from these studies suggest tha

  2024-08-07

  

  Genetic observations from these studies suggest that GMF regulates Arp2/3 complex and elastase dynamics in vivo13, 14. Budding yeast Gmf1 localizes to cortical actin patches, sites of endocytosis assembled by Arp2/3 13, 14. Furthermore, deletion of GMF1 exacerbates the growth defects of a cof1-22 mu

• Despite these efforts to prevent oxidative metabolic

  2024-08-07

  

  Despite these efforts to prevent oxidative metabolic degradation, and showed only marginal improvements in metabolic stability and still exhibited high plasma clearances as shown in . High molecular weight as well as relative high log values could be contributing factors to the poor PK profiles of

• Molecular docking is widely used to predict the interaction

  2024-08-07

  

  Molecular docking is widely used to predict the interaction between an enzyme and its inhibitors. This is a computational simulation approach that can be used as a tool to investigate the structure-activity relationship of ACE inhibitory peptides (Goodsell, 2009). It has been recently shown that ACE

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