• While the facial skeleton is formed by HOX negative neural

  2018-11-08

  

  While the facial skeleton is formed by HOX negative neural crest lpa receptor (Creuzet et al., 2002), the skeleton, originating from mesoderm-derived progenitor cells, is usually HOX positive in adults (Leucht et al., 2008). In bone regeneration experiments, Leucht et al. revealed that the HOX negat

• When BMSCs act as target cells

  2018-11-08

  

  When BMSCs act as target cells, the canonical β-catenin signaling pathway can be stimulated in response to Wnt1, Wnt3a, and Wnt8 or by inhibition of GSK-3 (Westendorf et al., 2004). Wnt/β-catenin directly stimulates Runx2 gene 69 9 via the TCF-binding site (Gaur et al., 2005). In the present study,

• Although colorectal CSCs Co CSCs were

  2018-11-08

  

  Although, colorectal CSCs (Co-CSCs) were originally identified as a small group of CD133+ dpn present in the primary tumors which exhibited high tumorigenicity in immunodeficient mice (O\'Brien et al., 2007; Ricci-Vitiani et al., 2007), some studies have shown that CD44+ colorectal cancer cells als

• br Acknowledgments We thank Mrs Jessica Franzot

  2018-11-08

  

  Acknowledgments We thank Mrs Jessica Franzot for technical support with Western blotting. This work was supported by grants from the government of the Friuli Venezia Giulia Region (SPINAL project), the Fund for Transregional Cooperation (MINA project), and the IBRO Return Home Programme Grant (to

• br Introduction Human embryonic and induced pluripotent stem

  2018-11-08

  

  Introduction Human embryonic and induced pluripotent stem cells (h/iPSCs) are of considerable interest in developmental biology and regenerative medicine, representing an enormous opportunity for generating patient-specific cells for screening drugs and cell therapies for various diseases. Stem c

• The finding that MHC and myogenin expression does not change

  2018-11-08

  

  The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l

• Immunohistochemical studies revealed increase in the proport

  2018-11-08

  

  Immunohistochemical studies revealed increase in the proportion of CD44highCD24low cell type from low in normal tissues to quite high in tumours. This is interesting as we know that Cancer Stem Cells are the actual tumour initiating subpopulation and can expand depending on its evolutionary landscap

• Recent reports have indicated the functional significance

  2018-11-08

  

  Recent reports have indicated the functional significance of FOXM1 in pluripotent cells. FOXM1 is required for the maintenance of pluripotency in mouse embryonal carcinoma (EC) cells, via direct regulation of Oct4 transcription (Xie et al., 2010). More importantly, FOXM1 is important for maintaining

• br Author disclosure statement br Acknowledgements Authors

  2018-11-08

  

  Author disclosure statement Acknowledgements Authors would like to thank Dr. T. Ramakrishna Murti for his valuable comments and linguistic corrections in the manuscript. Authors would also like to thank D.I Biotech (Seoul, Korea) for support to analyze neurite outgrowth. This work was support

• Next to the significant evidence that CpG

  2018-11-08

  

  Next to the significant evidence that CpG methylation of the HLA-G promoter is important for the transcriptional activity of the gene (Moreau et al., 2003; Mouillot et al., 2005), HLA-G Amyloid Beta-peptide (25-35) is also post-transcriptionally regulated by the 3′UTR. Several polymorphic sites in

• We have found a rare population

  2018-11-08

  

  We have found a rare population of pNSCs in the adult mammalian brain (termed AdpNSCs). We isolated cells from the adult periventricular region that generate clonally derived, self-renewing, and multipotent colonies in vitro in the presence of LIF. These LIF colonies can be passaged to give rise to

• A striking finding from this work is that in

  2018-11-08

  

  A striking finding from this work is that, in serum-free conditions, chicken PGCs can survive and proliferate in the absence of stem cell factor (SCF). SCF (c-KIT ligand) is a requisite survival factor for mouse PGCs at early embryonic stages and for survival in short-term culture experiments (Gu et

• In the present study we show that

  2018-11-08

  

  In the present study, we show that rhLNs are more effective in supporting xeno-free and defined differentiation compared with exogenous matrix such as gelatin, used in ongoing clinical studies (Schwartz et al., 2012). Moreover, we demonstrate that suspension transplantations of rhLN-521-hESC-RPE int

• br Results and Discussion br Experimental Procedures br

  2018-11-08

  

  Results and Discussion Experimental Procedures Author Contributions Acknowledgments We would like to thank Hospital de São João for bone marrow samples and buffy coats. This work had the financial support of FCT/MEC through National Funds and, when applicable, co-financed by the FEDER th

• Third we use a conceptually relevant measure to

  2018-11-07

  

  Third, we use a conceptually relevant measure to understand links between skin tone and health. Many prior studies have relied on a handheld narrow-band reflectance meter designed and validated for measuring skin pigmentation in a person\'s inner arm (e.g., Borrell, Kiefe, Williams, Diez-Roux, & Gor

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