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The mechanisms by which Cav enhances embryonal tumor progres
2019-07-02

The mechanisms by which Cav-1 enhances embryonal tumor progression are currently unknown. Given the documented ability of Cav-1 to drive increased biogenesis of caveolae and accelerate the flow of nutrients (mostly glucose and fatty acids) across the membrane, as observed in particular in adipocytes
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Grapiprant is a selective antagonist for prostaglandin E PGE
2019-07-02

Grapiprant () is a selective antagonist for prostaglandin E (PGE) receptor subtype 4 (EP4) identified as a clinical candidate for the treatment of inflammatory pain associated with osteoarthritis (OA). It is currently under development for use in humans and dogs. The projected dosing regimen of grap
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Several cholinesterase inhibitors have also been radiolabell
2019-07-01

Several cholinesterase inhibitors have also been radiolabelled with 11C as potential cholinesterase imaging agents. These include 11C-donepezil, 11C-methyltacrine, and 11C-physostigmine, which also have had limited success in demonstrating the known histochemically defined cholinesterase distributi
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Mouse This study focused on NPC L because it
2019-07-01

This study focused on NPC1L1 because it is critical for intestinal Mouse of both dietary and biliary cholesterol.1, 7, 8 Overall, regulation in the intestine of cholesterol, BAs, and lipids by FGF19 and SHP may involve the combined actions of regulation of other genes that were identified in our in
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In conclusion we observed that the
2019-07-01

In conclusion, we observed that the rate of carbapenem-resistant A. baumannii was high among burn patients. In addition, the most effective drugs against A. baumannii in vitro were colistin and polymyxin B. Since resistant isolates only had blaOXA-23-like and blaOXA-24-like, it seems that carbapenem
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Therefore if appropriate vitamin supplement
2019-07-01

Therefore, if appropriate vitamin supplement (>3 times/wk) for pregnant women would reduce the serum levels of copper, which has been demonstrated in the current issue of the , is it possible that the fetus might escape a potentially toxic bioaccumulation of mercury and copper? Of course, the fetus
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br Intrauterine insemination IUI is one of the more widely
2019-07-01

Intrauterine insemination (IUI) is one of the more widely used fertility treatments, and often suggested as the first choice for infertile couples with cervical infertility, mild male factor infertility, anovulation, mild or minimal endometriosis, and unexplained infertility with at least one pate
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br Case report A year old man with HCM
2019-07-01

Case report A 73-year-old man with HCM experienced palpitations for 6 months. A 12-lead electrocardiogram (ECG) obtained at a medical clinic showed a first-degree atrioventricular block (PR interval, 260ms), left ventricular hypertrophy (LVH) with strain-type negative T waves in V2–6 leads, and m
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br Epidemiology Electrophysiological BrS phenotypes occur
2019-07-01

Epidemiology Electrophysiological BrS phenotypes occur predominantly in young male adults (mglur rate, autonomic nervous system activity, some types of drugs, and a febrile state. Therefore, the true prevalence of BrS in the general population is difficult to estimate. However, the BrS prevalenc
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The lead ECG and dimensional geometrical maps for corrected
2019-07-01

The 12-lead ECG and 2-dimensional geometrical maps for corrected RT interval difference and corrected Tp–e interval difference obtained by using 187-ch RIDM-ECG before and during the intravenous amiodarone infusion for representative cases are shown in Figs. 1 and 2 respectively. The mean value of Q
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br Conflict of interest br Disclosures br Acknowledgments
2019-07-01

Conflict of interest Disclosures Acknowledgments Patient presentation A 64-year-old male with a history of a right ventricular outflow tract ventricular tachycardia (RVOT-VT) ablation presented from an outlying hospital due to four recent episodes of non-exertional syncope. He had three
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The appearance of J wave or ER is now recognized
2019-07-01

The appearance of J wave or ER is now recognized to predispose to the development of arrhythmogenesis when associated with other cardiac disorders, such as ischemia, phosphodiesterase inhibitor failure, and hypothermia. The J wave might predict prognosis of cardiac events in various heart diseases,
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To date over mutations in KCNQ have been
2019-07-01

To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [
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La sensaci n de desmoronamiento y de
2019-07-01

La sensación de desmoronamiento y de vértigo nace en “Lumbre en el aire” de la confusión de lo terrestre con lo estelar o sideral. Mientras los signos “jardines”, “mar” o “rocas” remiten a realidades telúricas, “cielo”, “astros”, “cometas”, “aerolitos” “galaxia” sitúan al lector en la dimensión cósm
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Tricot muestra las entra as del Movimiento Mapuche Autonomis
2019-07-01

Tricot muestra las entrañas del Movimiento Mapuche Autonomista con la intención de conducir al lector en la comprensión de la resistencia actual de autoafirmación “ora como pueblo-nación, ora como Identidad Territorial específica”; afirma que el movimiento mapuche “no es un proceso lineal, sino más
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